{"id":4148,"date":"2026-03-09T21:25:16","date_gmt":"2026-03-09T19:25:16","guid":{"rendered":"https:\/\/life4hsp.com\/?p=4148"},"modified":"2026-03-09T21:51:48","modified_gmt":"2026-03-09T19:51:48","slug":"update-onderzoek-venglustat-bij-ap5-gerelateerde-hsp","status":"publish","type":"post","link":"https:\/\/life4hsp.com\/fr\/update-onderzoek-venglustat-bij-ap5-gerelateerde-hsp\/","title":{"rendered":"Mise \u00e0 jour sur la recherche Venglustat pour la HSP li\u00e9e \u00e0 AP5"},"content":{"rendered":"

Il y a des nouvelles importantes concernant notre \u00e9tude en cours sur des souris avec le\u00a0<\/span>Venglustat<\/span><\/b>\u00a0en tant que traitement potentiel pour les sous-types de HSP SPG11, SPG15 et SPG48.\u00a0<\/span>SPG11, SPG15 en SPG48.<\/p>\n

Des \u00e9tudes ant\u00e9rieures ont montr\u00e9 que le Venglustat peut r\u00e9duire l'accumulation de lipides nocifs dans les cellules nerveuses et ainsi am\u00e9liorer la motricit\u00e9 et le comportement chez les souris malades. Dans notre \u00e9tude actuelle, nous testons diff\u00e9rentes doses et dur\u00e9es de traitement afin de\u00a0<\/span>d\u00e9terminer ce qui est s\u00fbr et efficace \u00e0 long terme.<\/span>\u00a0<\/span><\/p>\n

Que montrent les premiers r\u00e9sultats ?<\/span><\/b>\u00a0<\/span><\/p>\n

Les r\u00e9sultats interm\u00e9diaires montrent qu'une dose trop \u00e9lev\u00e9e sur le long terme est moins efficace que pr\u00e9vu. Il s'agit d'une d\u00e9couverte importante et pr\u00e9cieuse. C'est pourquoi nous avons adapt\u00e9 le protocole de recherche et ajout\u00e9 un groupe suppl\u00e9mentaire de souris recevant une dose plus faible pendant une p\u00e9riode plus longue. Nous voulons ainsi trouver le meilleur \u00e9quilibre entre efficacit\u00e9 et s\u00e9curit\u00e9.<\/span>\u00a0<\/span><\/p>\n

\"Update<\/p>\n

Pourquoi est-ce important ?<\/span><\/b>\u00a0<\/span><\/p>\n

D\u00e9terminer la dose correcte est une \u00e9tape cruciale dans le d\u00e9veloppement de nouveaux m\u00e9dicaments. Les connaissances que nous acqu\u00e9rons maintenant sont essentielles pour appliquer ce traitement en toute s\u00e9curit\u00e9 chez l'homme \u00e0 l'avenir.<\/span>\u00a0<\/span><\/p>\n

Soutien n\u00e9cessaire<\/span><\/b>\u00a0<\/span><\/p>\n

Jusqu'\u00e0 pr\u00e9sent,\u00a0<\/span>Euro-HSP<\/span><\/b><\/a>\u00a0<\/span><\/b>et\u00a0<\/span>Life4HSP<\/span><\/b><\/a>\u00a0<\/span><\/b>ont collect\u00e9 pr\u00e8s de 200 000 \u20ac, mais il reste encore 100 000 \u20ac n\u00e9cessaires pour terminer l'\u00e9tude compl\u00e8te. Votre soutien est crucial pour poursuivre cette recherche prometteuse.<\/span>\u00a0<\/span><\/p>\n

Lees cliquez ici<\/a> de volledige samenvatting van het onderzoek<\/span><\/b><\/p>\n

\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Er is belangrijk nieuws over ons lopende\u00a0muizenonderzoek naar\u00a0Venglustat\u00a0als mogelijke behandeling voor de HSP-subtypes\u00a0SPG11, SPG15 en SPG48. Eerdere studies lieten zien dat\u00a0Venglustat\u00a0de ophoping van schadelijke vetstoffen in zenuwcellen kan verminderen en zo beweging en gedrag bij zieke muizen kan verbeteren. In ons huidige onderzoek testen we verschillende doseringen en behandelduur om te bepalen\u00a0wat veilig en effectief […]<\/p>\n","protected":false},"author":6,"featured_media":4154,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[13],"tags":[],"class_list":["post-4148","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-onderzoek"],"acf":[],"yoast_head":"\nUpdate onderzoek Venglustat bij AP5-gerelateerde HSP - Life4HSP<\/title>\n<meta name=\"description\" content=\"Tussentijdse resultaten van het Venglustat-onderzoek bij AP5-gerelateerde HSP. 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