{"id":4148,"date":"2026-03-09T21:25:16","date_gmt":"2026-03-09T19:25:16","guid":{"rendered":"https:\/\/life4hsp.com\/?p=4148"},"modified":"2026-03-09T21:51:48","modified_gmt":"2026-03-09T19:51:48","slug":"update-onderzoek-venglustat-bij-ap5-gerelateerde-hsp","status":"publish","type":"post","link":"https:\/\/life4hsp.com\/es\/update-onderzoek-venglustat-bij-ap5-gerelateerde-hsp\/","title":{"rendered":"Actualizaci\u00f3n sobre la investigaci\u00f3n de Venglustat en HSP relacionada con AP5"},"content":{"rendered":"

Hay noticias importantes sobre nuestro estudio en curso en ratones con\u00a0<\/span>Venglustat<\/span><\/b>\u00a0como posible tratamiento para los subtipos de HSP SPG11, SPG15 y SPG48.\u00a0<\/span>SPG11, SPG15 en SPG48.<\/p>\n

Estudios anteriores han mostrado que Venglustat puede reducir la acumulaci\u00f3n de l\u00edpidos da\u00f1inos en las c\u00e9lulas nerviosas y as\u00ed mejorar el movimiento y el comportamiento en ratones enfermos. En nuestro estudio actual estamos probando diferentes dosis y duraciones de tratamiento para determinar\u00a0<\/span>lo que es seguro y eficaz a largo plazo.<\/span>\u00a0<\/span><\/p>\n

\u00bfQu\u00e9 muestran los primeros resultados?<\/span><\/b>\u00a0<\/span><\/p>\n

Los resultados intermedios muestran que una dosis demasiado alta a largo plazo funciona menos bien de lo esperado. Este es un hallazgo importante y valioso. Por ello, hemos adaptado el protocolo de investigaci\u00f3n y a\u00f1adido un grupo adicional de ratones que recibe una dosis m\u00e1s baja durante m\u00e1s tiempo. Esto nos permitir\u00e1 encontrar el mejor equilibrio entre eficacia y seguridad.<\/span>\u00a0<\/span><\/p>\n

\"Update<\/p>\n

\u00bfPor qu\u00e9 es importante?<\/span><\/b>\u00a0<\/span><\/p>\n

Determinar la dosis correcta es un paso crucial en el desarrollo de nuevos medicamentos. El conocimiento que estamos adquiriendo ahora es esencial para poder aplicar este tratamiento de manera segura en humanos en el futuro.<\/span>\u00a0<\/span><\/p>\n

Apoyo necesario<\/span><\/b>\u00a0<\/span><\/p>\n

Hasta ahora,\u00a0<\/span>Euro-HSP<\/span><\/b><\/a>\u00a0<\/span><\/b>y\u00a0<\/span>Life4HSP<\/span><\/b><\/a>\u00a0<\/span><\/b>han recaudado casi 200.000 \u20ac, pero a\u00fan se necesitan otros 100.000 \u20ac para completar toda la investigaci\u00f3n. Su apoyo es fundamental para continuar con esta prometedora investigaci\u00f3n.<\/span>\u00a0<\/span><\/p>\n

Lees hier<\/a> de volledige samenvatting van het onderzoek<\/span><\/b><\/p>\n

\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Er is belangrijk nieuws over ons lopende\u00a0muizenonderzoek naar\u00a0Venglustat\u00a0als mogelijke behandeling voor de HSP-subtypes\u00a0SPG11, SPG15 en SPG48. Eerdere studies lieten zien dat\u00a0Venglustat\u00a0de ophoping van schadelijke vetstoffen in zenuwcellen kan verminderen en zo beweging en gedrag bij zieke muizen kan verbeteren. In ons huidige onderzoek testen we verschillende doseringen en behandelduur om te bepalen\u00a0wat veilig en effectief […]<\/p>\n","protected":false},"author":6,"featured_media":4154,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[13],"tags":[],"class_list":["post-4148","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-onderzoek"],"acf":[],"yoast_head":"\nUpdate onderzoek Venglustat bij AP5-gerelateerde HSP - Life4HSP<\/title>\n<meta name=\"description\" content=\"Tussentijdse resultaten van het Venglustat-onderzoek bij AP5-gerelateerde HSP. 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