{"id":4148,"date":"2026-03-09T21:25:16","date_gmt":"2026-03-09T19:25:16","guid":{"rendered":"https:\/\/life4hsp.com\/?p=4148"},"modified":"2026-03-09T21:51:48","modified_gmt":"2026-03-09T19:51:48","slug":"update-onderzoek-venglustat-bij-ap5-gerelateerde-hsp","status":"publish","type":"post","link":"https:\/\/life4hsp.com\/en\/update-onderzoek-venglustat-bij-ap5-gerelateerde-hsp\/","title":{"rendered":"Research Update on Venglustat for AP5-Related HSP"},"content":{"rendered":"

We would like to share an important update on our ongoing mouse study investigating\u00a0<\/span>Venglustat<\/span><\/b>\u00a0as a possible treatment for the HSP subtypes SPG11, SPG15 and SPG48.\u00a0<\/span>SPG11, SPG15 en SPG48.<\/p>\n

Earlier studies showed that Venglustat can reduce the build-up of harmful fats in nerve cells and improve movement and behavior in affected mice. In our current study, we are testing different doses and treatment durations to find out what is safe\u00a0<\/span>and effective in the long term.<\/span>\u00a0<\/span><\/p>\n

What do the first results show?<\/span><\/b>\u00a0<\/span><\/p>\n

The interim results suggest that a very high dose is less effective over longer periods than expected. This is an important and valuable finding. As a result, we have adjusted the study design and added an extra group of mice receiving a lower dose for a longer time. This will help us find the best balance between effect and safety.<\/span>\u00a0<\/span><\/p>\n

\"Update<\/p>\n

Why is this important?<\/span><\/b>\u00a0<\/span><\/p>\n

Finding the right dose is a key step in drug development. The knowledge we gain now is essential to safely translate this treatment from the laboratory to patients.<\/span>\u00a0<\/span><\/p>\n

Support needed<\/span><\/b>\u00a0<\/span><\/p>\n

So far,\u00a0<\/span>Euro-HSP<\/span><\/b><\/a>\u00a0<\/span><\/b>and\u00a0<\/span>Life4HSP<\/span><\/b><\/a>\u00a0<\/span><\/b>have raised around \u20ac200,000, but another \u20ac100,000 is needed to complete the study. Your support is crucial to continue this promising research.<\/span>\u00a0<\/span><\/p>\n

Read here<\/a> the full study summary in Dutch en English translation here<\/span><\/b><\/p>\n

\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Er is belangrijk nieuws over ons lopende\u00a0muizenonderzoek naar\u00a0Venglustat\u00a0als mogelijke behandeling voor de HSP-subtypes\u00a0SPG11, SPG15 en SPG48. Eerdere studies lieten zien dat\u00a0Venglustat\u00a0de ophoping van schadelijke vetstoffen in zenuwcellen kan verminderen en zo beweging en gedrag bij zieke muizen kan verbeteren. In ons huidige onderzoek testen we verschillende doseringen en behandelduur om te bepalen\u00a0wat veilig en effectief […]<\/p>\n","protected":false},"author":6,"featured_media":4154,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[13],"tags":[],"class_list":["post-4148","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-onderzoek"],"acf":[],"yoast_head":"\nUpdate onderzoek Venglustat bij AP5-gerelateerde HSP - Life4HSP<\/title>\n<meta name=\"description\" content=\"Tussentijdse resultaten van het Venglustat-onderzoek bij AP5-gerelateerde HSP. 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